DENV4SEQ10

Peptide Sequence

Leu Trp His Pro Gly His Asp Arg Phe Asn Ile Thr Val

Single Letter Code: LWHPGHDRFNITV

3D Structure Visualization

ADMET Properties

Comprehensive Drug Property Analysis

Absorption

  • Water solubility -2.892 (log mol/L)
  • Caco2 permeability -1.002 (log Papp in 10-6 cm/s)
  • Intestinal absorption (human) 0 (% Absorbed)
  • Skin Permeability -2.735 (log Kp)
  • P-glycoprotein substrate Yes
  • P-glycoprotein I inhibitor No
  • P-glycoprotein II inhibitor No

Distribution

  • VDss (human) -0.032 (log L/kg)
  • Fraction unbound (human) 0.385 (Fu)
  • BBB permeability -3.417 (log BB)
  • CNS permeability -7.934 (log PS)

Metabolism

  • CYP2D6 substrate No
  • CYP3A4 substrate No
  • CYP1A2 inhibitior No
  • CYP2C19 inhibitior No
  • CYP2C9 inhibitior No
  • CYP2D6 inhibitior No
  • CYP3A4 inhibitior No

Excretion

  • Total Clearance -0.249 (log ml/min/kg)
  • Renal OCT2 substrate No

Toxicity

  • AMES toxicity No
  • Max. tolerated dose (human) 0.438 (log mg/kg/day)
  • hERG I inhibitor No
  • hERG II inhibitor No
  • Oral Rat Acute Toxicity (LD50) 2.482 (mol/kg)
  • Oral Rat Chronic Toxicity (LOAEL) 9.646 (log mg/kg_bw/day)
  • Hepatotoxicity Yes
  • Skin Sensitisation No
  • T.Pyriformis toxicity 0.285 (log ug/L)
  • Minnow toxicity 18.54 (log mM)